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Characterization of non‐C 2 symmetric salen ligands as novel antimicrobial and antifungal agents
Author(s) -
Allgood Cory W.,
Wolyniak Michael J,
Deifel Nicholas P
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.650.2
Subject(s) - salicylaldehyde , catalysis , antifungal , chemistry , ligand (biochemistry) , antimicrobial , combinatorial chemistry , carbene , nuclear magnetic resonance spectroscopy , metal , homogeneous catalysis , organic chemistry , stereochemistry , schiff base , biochemistry , microbiology and biotechnology , biology , receptor
The importance of salen ligands in homogeneous catalysis and material chemistry/biochemistry has unambiguously been demonstrated in procedures that include the synthesis of C 2 ‐symmetrical complexes that are used as catalysts for many organic conversions with industrial applications. Of late, research on salen ligands has turned to the potential for non‐C 2 symmetric ligands to act asantimicrobials and antifungals. As drug‐resistant microbes become a larger threat to public health, novel compounds like non‐C 2 symmetric salen ligands could be an invaluable resource for disease control. Here, a practical synthesis of a non‐C 2 symmetric salen ligand is described using a 1:1:1 molar ratio of phenylenediamine and two different salicylaldehyde's which can be important in testing catalytic properties along with antimicrobial activity. Specially, we have built a non‐C 2 symmetric ligand using varying R groups and metal complexes and have characterized the resultant product using 13 C‐ NMR, 1 H‐NMR, infrared spectroscopy, and gas chromatography‐mass spectroscopy. Current research focuses on the use of metal ions such as iron and zinc in the formation of efficient and cost‐effective novel antimicrobial and antifungal compounds that can be tested using Kirby‐Bauer analyses. Support or Funding Information Hampden‐Sydney College Office of Undergraduate Research This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .