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Study the Effect of Irisin on Prostate Cancer Cells
Author(s) -
Ko FuHsuan,
Huang FengTing
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.647.16
Subject(s) - myokine , prostate cancer , cancer , cancer research , cancer cell , prostate , medicine , cell growth , carcinogenesis , metastasis , apoptosis , endocrinology , oncology , biology , skeletal muscle , biochemistry
According to the World Health Organization, prostate cancer is the second most common type of cancer and the fifth leading cause of cancer‐related death in men around the world. Epidemiological studies demonstrate that exercise can improve survival and reduce recurrence of prostate cancer. Studies indicate that humans' exercise serum has a growth inhibitory effect on prostate cancer cell proliferation, but which factor plays a major role is not clear. Recently, myokines secreted by skeletal muscle are believed to take part in cancer suppression. Irisin, an exercise‐induced myokine, promotes the “browning” of white adipocytes to brown‐like adipocytes. Several studies have demonstrated that irisin can inhibit cell progression in various cancer cells including those of breast cancer, lung cancer, and osteosarcoma. However, the underlying mechanisms of irisin's inhibitory effects on prostate cancer growth are not yet completely understood. Our present study reveals that human recombinant irisin expressed in the E. coli system can inhibit cell migration and invasion of two prostate cancer cell lines, PC3 and 22Rv1. Irisin suppresses the proliferation of prostate cancer cells in a dose‐dependent manner, in addition to inducing cell cycle arrest and apoptosis in prostate cancer cells. These findings support the possibility of irisin treatment as a new therapeutic strategy against prostate cancer. Support or Funding Information This study was supported by the Department of Biochemical Science of Technology of National Taiwan University and the Taiwan Ministry of Science and Technology. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .