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Gut Check on Air Pollution: Effects of Biodiesel Ultrafine Particles on Gut Microbial Metabolism
Author(s) -
Zhu Jiangjiang
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.639.7
Subject(s) - gut flora , biodiesel , population , food science , metabolomics , microbiome , biology , microbial metabolism , chemistry , bacteria , biochemistry , medicine , environmental health , bioinformatics , catalysis , genetics
Emerging evidence has highlighted the need for scientists, physicians, and policy‐makers to understand the adverse health effect of air pollution substances, such as ultrafine to overall human health, through their complicated modulation of human gut microbiota. Therefore, this study will focus on deciphering the interactive modulating effects of gastrointestinal (GI) UFPs exposure to gut microbial composition and functions, then eventually to enable systematic evaluation of the impact of UFPs to host health. Due to the increasing importance of biodiesel to our society, and the vastly lacking information to their health effect, the UFPs generated from combustion of both petrodiesel (B0) and petrodiesel/biodiesel blend (80:20 v/v, B20) in a representative light‐duty diesel engine were used in this study. An in vivo murine model with both male and female groups was applied for investigating gut microbial population and diversity changes during frequent UFP exposure. Multi‐omics approaches, including targeted and untargeted metabolomics, and microbiome analysis were applied for evaluating the UFP‐induced gut microbial population and functional changes. We discovered that the concentration and relative abundance of bacterial metabolites from the host gut were depended on the percentage biodiesel in the fuel blends (B0 vs. B20). Correlation analysis was conducted to obtain the relationship between UFPs composition and gut microbial metabolic profiles. Bacterial cellular oxidative stress and their metabolic signatures, such as the decreased concentration of nucleotides and lipids and increased concentrations of carbohydrate, energy and vitamin metabolites are examined via metabolomics approaches. Furthermore, the altered metabolites are correlated to microbial composition changes.Graphic abstractThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .