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Antimicrobial Activity of 3, 4‐Annelated Coumarin‐Benzodiazepine‐Systems
Author(s) -
Govori Sevdije,
Ibrahimi Hamide,
Daci Majlinda,
Haziri Arben
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.634.4
Subject(s) - christian ministry , antimicrobial , coumarin , escherichia coli , chemistry , proton nmr , combinatorial chemistry , library science , stereochemistry , political science , organic chemistry , computer science , biochemistry , law , gene
This study presents the synthesis of 7‐iminobenzo[b]chromeno[4,3‐e][1,4]diazepin‐6(7H)‐ones ( 3–4 ) by simple reaction of 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbonitrile with o‐phenylidenediamine. The compounds ( 3–4 ) were characterized by elemental analysis data, IR, 1H NMR and mass spectral data. The novel heterocyclic compounds were evaluated for antimicrobial activity against Escherichia coli and Staphylococus aureus using the Kirby‐Bayer method. The novel compounds demonstrated moderate antimicrobial activity. Support or Funding Information Funding: Support for this study was provided by the Ministry of Education, Science and Technology of the Republic of Kosovo. Grant number:2‐5521‐2 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .