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Bite morphology of erythrocytes with G6PD deficiency is or is not a reliable parameter for forensic identification
Author(s) -
Cusimano Maurizio
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.612.14
Subject(s) - glucosephosphate dehydrogenase deficiency , morphology (biology) , giemsa stain , biology , glucose 6 phosphate dehydrogenase , forensic science , staining , genetics , pathology , medicine , enzyme , dehydrogenase , biochemistry
Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide. It has a high prevalence in persons of African descent. It is inherited as an X‐linked recessive disorder. G6PD deficiency is polymorphic, with more than 300 variants. 50 crime scenes were analyzed with microscopic examination of blood stains. The morphology of erythrocytes after controlled rehydration was examined under a microscope with May‐Grunwald Giemsa staining. In the 50 samples the RBC diameter, the morphology, the presence of Heinz's bodies and the presence of Bite erythrocytes were evaluated. On the samples the G6PD was analyzed. In 7 cases, typical changes in G6PD deficiency were identified. In the analyzed cases, DNA analysis was performed on other tests in the same scene. The result of the study was that in the 7 cases identified, these were black subjects. the conclusion is that the evaluation of the erythrocyte morphology is a reliable test (p <0.05) for the identification of black race of subjects without identity in the absence of other evidence. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .