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Dietary TMAO Exerts Beneficial Effects in Heart Failure Rats
Author(s) -
Ufnal Marcin,
Huc Tomasz,
Drapala Adrian,
Samborowska Emilia,
Konop Marek
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.592.11
Subject(s) - heart failure , medicine , cardiomyopathy , diastolic heart failure , cardiac function curve , endocrinology , diastole , ventricle , circulatory system , fibrosis , cardiology , blood pressure
Increased plasma trimethylamine oxide (TMAO) has been suggested to be a marker of cardiovascular risk. However, mechanisms of the increase and biological effects of TMAO are obscure. Plasma TMAO originates from gut bacteria‐produced TMA, and from dietary TMAO e.g. seafood. Male, 6‐week‐old, Spontaneously‐Hypertensive‐Heart‐Failure rats (SHHF, SHHF/MccGmiCrl‐Leprcp/Crl, Charles River Laboratories, USA) and 4–5‐week‐old Spontaneously Hypertensive Rats (SHR, Medical University of Warsaw, Poland) were divided into Water‐groups and TMAO‐groups (drinking TMAO water solution 0.33g/L). Age‐matched Wistar‐Kyoto (WKY) were used as healthy controls. After one year of observation survival was 100% in WKY, SHHF‐TMAO, SHR‐Water and SHR‐TMAO but only 66% in SHHF‐Water. WKY showed no pathological changes in the circulatory system. SHHF showed heart failure with reduced systolic function and hypertrophic cardiomyopathy with histopathological picture of transition from hypertrophic to dilated cardiomyopathy. SHR showed heart failure with reduced diastolic function and hypertrophic cardiomyopathy. In comparison to SHHF‐Water, SHHF‐TMAO had 3‐fold higher plasma TMAO, a significantly lower sympathetic/vagal ratio, and a trend toward lower cardiac fibrosis. In comparison to SHR‐Water, SHR‐TMAO had 4–5‐fold increase in plasma TMAO, significantly lower plasma NT‐proBNP, significantly lower left ventricle end‐diastolic‐pressure and significantly lower cardiac fibrosis. In conclusion, 3–5‐fold increase in plasma TMAO does not exert negative effects on the circulatory system in heart failure rats. In contrast, increased dietary TMAO seems to exert beneficial effect in heart failure, however, its magnitude may vary in different models or in different stages of heart failure. Support or Funding Information Supported by National Science Centre, Poland grant no. 2015/19/N/NZ5/00650 and 2016/21/B/NZ5/02544. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .