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Effect of aqueous extract of Tamarindus indica Linn. (Leguminosae) pulp on basal and stimulated gastric acid secretion due to histamine, pentagastrin and carbachol in rats
Author(s) -
Onwuchekwa Chinedu,
Okon Bassey
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.583.7
Subject(s) - pentagastrin , histamine , carbachol , gastric acid , basal (medicine) , medicine , pharmacology , chemistry , traditional medicine , stomach , stimulation , insulin
Local folklore claims that Tamarindus indica Linn. (Leguminosae) has a gastric beneficial role in humans ( Pankaj et al., 2011). This study was carried out to examine the effects of tamarind on basal and stimulated gastric acid secretion (GAS) in the Wistar rats. Four groups of rats consisting of 6 rats (180 – 210 g) each were treated with aqueous extract of tamarind pulp (1.5 mg/kg, 2.5 mg/kg and 4 mg/kg) orally for 21 days. The ethical guidelines in accordance with NIH Guide for care and use of laboratory animals were followed in the handling of the animals during the studies. At the last day of the treatment, the rats were fasted for 24 hours, anaesthetized with ketamine and cannulated through the femoral vein. GAS (mEq/l −1 ) induced by histamine, pentagastrin and carbachol administration were assessed by using modified continuous perfusion technique method of Ghosh and Schild (1958) and its acidity determined by titration method. Data were expressed as mean ± SEM. Student's t‐test and one way ANOVA were used to analyze and determine levels of significance at p=0.05. The aqueous extract of tamarind significantly decreased (p<0.05) GAS induced by the histamine, pentagastrin and carbachol at small and medium doses, but not at higher doses over the 80 minute's period in all the treated groups. The gastroprotective action of tamarind may be multifactorial that may include anti‐secretory action. Support or Funding Information The financial support of Usmanu Danfodiyo University, Sokoto Nigeria is acknowledged This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .