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Sympathetic Transduction in Young Women with a Family History of Hypertension
Author(s) -
McGinty Shane J.,
Babcock Matthew C.,
Matthews Evan L.,
Greaney Jody L.,
Wenner Megan M.
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.562.9
Subject(s) - microneurography , blood pressure , supine position , medicine , photoplethysmogram , heart rate , cardiology , family history , cold pressor test , baroreflex , population , sympathetic nervous system , endocrinology , environmental health , filter (signal processing) , computer science , computer vision
Exaggerated sympathetic transduction has recently been demonstrated in certain populations of young adults at risk for future hypertension. Our laboratory has previously reported that young women with a family history of hypertension (+FH), a population with a greater risk for future hypertension, have exaggerated sympathetic and blood pressure (BP) reactivity compared to women without a family history of hypertension (−FH). However, it is unclear whether resting sympathetic transduction may partially explain the exaggerated BP reactivity in +FH women. PURPOSE Therefore, the purpose of this study was to test the hypothesis that +FH young women would display augmented pressor responses following spontaneous bursts of muscle sympathetic nerve activity (MSNA) at rest. METHODS We retrospectively examined beat‐by‐beat BP (finger photoplethysmography) and MSNA (peroneal microneurography) in 5 +FH (22 ± 1 yr, 20 ± 2 kg/m 2 ) and 7 −FH young women (24 ± 3 yr, 21 ± 1 kg/m 2 ) during 10 minutes of supine rest. Signal averaging was used to characterize changes in BP for the 10 cardiac cycles following spontaneous MSNA bursts. Resting baseline variables were compared using unpaired t‐tests. A 2‐way repeated measures ANOVA was used to compared BP changes over 10 cardiac cycles following a burst of MSNA, and peak BP changes were compared using unpaired t‐tests. Data are presented as mean ± SD. RESULTS Resting mean arterial pressure (MAP) (+FH: 76 ± 12 vs. −FH: 83 ± 19 mmHg, p=0.72), MSNA (+FH: 8 ± 2 vs. −FH: 8 ± 5 bursts/min, p=0.89), heart rate (+FH: 70 ± 13 vs. −FH: 61 ± 4 bpm, p=0.12), and total peripheral resistance (+FH: 1811 ± 683 vs. −FH: 1432 ± 293 mmHg·min/mL, p=0.77) were not different between groups. Following spontaneous bursts of MSNA, the increase in MAP over the subsequent 10 cardiac cycles was not different between groups (time: p<0.01, group: p=0.16, interaction: p=0.89). Additionally, the peak change in MAP (+FH: Δ 1.5 ± 0.9 vs. −FH: Δ 2.4 ± 1.8 mmHg, p=0.35) systolic BP (+FH: Δ 1.6 ± 1.2 vs. −FH: Δ 3.7 ± 2.2 mmHg, p=0.18) and diastolic BP (+FH: Δ 2.2 ± 0.9 vs. −FH: Δ 3.5 ± 2.9 mmHg, p=0.73) were not different between groups. CONCLUSIONS These preliminary data suggest that sympathetic transduction following a burst of MSNA at rest does not elicit greater increases in BP in +FH young women. Further research is needed in order to more specifically examine whether the degree to which a sympathetic burst influences vascular tone is altered in +FH women. Support or Funding Information Supported by NIH Grant P20 GM 113125, P20 GM 103446, U54 GM 104941, and The University of Delaware Research Foundation This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .