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NIH's Consortium on Molecular Transducers of Physical Activity (MoTrPAC)
Author(s) -
Williams John P.,
Joseph Lyndon,
Consortium MoTrPAC
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.551.1
Subject(s) - physical activity , medicine , human health , health benefits , gerontology , physical therapy , environmental health , traditional medicine
Physical activity is beneficial to human health and well being across the lifespan. Regular physical activity brings about numerous health benefits, however most of the current studies are correlative and the molecular mechanisms that are the basis for these beneficial effects remain obscure. The NIH Common Fund initiated the Molecular Transducers of Physical Activity Consortium (MoTrPAC) in December 2016 by issuing 19 grants to 37 Principal Investigators from 23 institutions. The goals of MoTrPAC are to:Aim 1: Assemble a comprehensive map of the molecular changes that occur in response to exercise and provide insights into how they are altered by age, sex, body composition and fitness level. Aim 2: Develop a user‐friendly database to facilitate investigator‐initiated studies and catalyze the field of physical activity research whereby researchers can develop hypotheses exploring novel mechanisms by which physical activity improves or preserves health.MoTrPAC is a large discovery project that will explore and document molecular signatures/markers of the exercise response to physical activity in humans and animals. The human studies are a multi‐center clinical trial cohort of people from 10–80 years of age. Animal studies have been conducted and tissues harvested from 6 and 18‐month old F344 rats before and at seven time points post acute exercise. Other rats underwent a training regime ranging from one to eight weeks and tissues harvested 48 hours after the last bought. Three of the animal tissues harvested are the same as those harvested from human subjects. A total of 18 tissues were harvested from rats. Multiple state of art and omics platforms including genomic, transcriptomic, epigenomic, proteomic and metabolomics will be employed to collect extensive data sets that will serve as a basis for future investigator initiated studies for the research community to advance our understanding of the molecular mechanisms of exercises effects. This presentation will describe various components of MoTrPAC consortium and provide information on its current activities. Support or Funding Information NIH Common Fund; Office of the NIH Director This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .