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The Effects of 16‐hour Nighttime Fasting on Markers of Oxidative Stress
Author(s) -
DirksNaylor Amie J,
Wilson Jennifer A.,
Waghel Rashi,
Bush Mark,
Cook Corbin
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.543.12
Subject(s) - tbars , intermittent fasting , medicine , oxidative stress , regimen , caloric theory , lipid peroxidation , glutathione reductase , thiobarbituric acid , morning , antioxidant , endocrinology , physiology , glutathione peroxidase , biochemistry , chemistry , superoxide dismutase
Caloric restriction and intermittent fasting have shown to confer a plethora of health benefits. However, traditional regimens of caloric restriction (restricting caloric intake by 30–40% every day) and intermittent fasting (fasting every other day), have proven difficult to comply. Prolonged nighttime fasting is a type of intermittent fasting which may be an easier regimen to maintain, but has been scarcely studied. Thus, the aim of this study was to determine the effects of this regimen on biomarkers of oxidative stress. Eleven healthy men ranging in age from 21–39 years fasted for 16‐hrs (~6pm–10am) each night for 4‐weeks. Subjects were instructed to eat their normal diet outside of the suggested fasting hours. Pre‐ and post‐fasting blood samples were collected. 24‐hr food and drink intake was self‐recorded periodically before and during the fasting period using the National Cancer Institute Automated Self‐Administered 24‐hour Recall (ASA24) website. Total antioxidant capacity, DNA oxidation, thiobarbituric acid reactive substances (TBARS), and glutathione reductase (GR) activity were measured in pre‐ and post‐plasma samples. Prolonged nighttime fasting increased plasma total antioxidant capacity (p=0.001), but did not affect DNA oxidation, lipid peroxidation, or GR activity. There was no difference in the 24‐hr recall caloric intake before and after starting the fasting regimen. The fasting regimen also did not affect the percent intake of proteins, carbohydrates, fats, sugar, or fiber. Thus, the results suggest that prolonged nighttime fasting, without altering daily caloric or dietary intake, may improve antioxidant capacity. Support or Funding Information None This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .