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Evidence of a Shear Stress Stimulus Profile Dependent Impact of Cycling Training on Flow‐Mediated Dilation
Author(s) -
King Trevor James,
Pyke Kyra
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.541.14
Subject(s) - brachial artery , medicine , cardiology , stimulus (psychology) , reactive hyperemia , blood flow , blood pressure , psychology , psychotherapist
Lower limb endurance training can improve conduit artery flow‐mediated dilation (FMD) in response to transient increases in shear stress (reactive hyperemia; RH‐FMD) in both the upper and lower limbs. Sustained increases in shear stress recruit a partially distinct transduction pathway and elicit a physiologically relevant FMD response that appears to provide distinct information regarding endothelial function (sustained shear stress‐FMD, SS‐FMD). However, the impact of training on SS‐FMD is not well understood. PURPOSE To determine the impact of cycling training on handgrip exercise induced brachial artery (BA) FMD (BA SS‐FMD) and calf plantar‐flexion induced superficial femoral artery (SFA) FMD (SFA SS‐FMD). METHODS 28 young males were randomized to control (n=12) or training (n=16) groups. Participants in the training group cycled 30 min/day, 3 days/week for 4 weeks at 80 % heart rate reserve. RH‐FMD and SS‐FMD was assessed in the BA and SFA pre and post‐intervention via Duplex ultrasound. RESULTS Data are mean ±SD. Training did not impact SS‐FMD in either artery, and RH‐FMD in the SFA was also unchanged (p>0.05). When controlling for the shear rate stimulus via covariate analysis, BA RH‐FMD improved in the training group (p=0.05) (Control: pre‐ 5.7 ± 2.4%, post‐ 5.3 ± 2.4%; training: pre‐ 5.4 ± 2.5%, post‐ 7.2 ± 2.4%). CONCLUSIONS Endurance training resulted in non‐uniform adaptations to endothelial function, with an isolated impact on the brachial artery, and on the ability to transduce a transient increase in shear stress. Support or Funding Information Funded by NSERC This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .