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Heat treatment attenuates the exaggerated exercise pressor reflex in rats with peripheral artery disease
Author(s) -
Xing Jihong,
Lu Jian,
Li Jianhua
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.540.8
Subject(s) - medicine , reflex , peripheral , contraction (grammar) , femoral artery , blood pressure , mean arterial pressure , stimulation , endocrinology , anesthesia , heart rate
Femoral artery occlusion in rats has been used to study human peripheral artery disease (PAD). The responses of blood pressure (BP) and sympathetic nerve activity are exaggerated during static exercise in PAD rats with femoral artery occlusion. The purpose of the current study was to examine if heat treatment (a prior heat exposure) has beneficial effects on the exaggerated exercise pressor reflex in PAD rats. Basal muscle temperature (Tm) was 35.6±0.1 °C in control rats (n=3); and 34.2±0.1 °C in PAD rats (n=5; P <0.05 vs . control rats). As Tm was increased by ~1.5 °C and this was maintained for 30 min, core temperature was not altered in control group and PAD group. The heat treatment was performed 2 times daily for 3 days. Then we examined the BP response to static muscle contraction. The greater mean arterial pressure (MAP) response was observed in PAD rats (31±5 mmHg in PAD rats/n=6 vs . 22±3 mmHg in control rats/n=8; P <0.05). Heat treatment attenuated amplification of BP response in PAD rats (MAP response: 24±3 mmHg in PAD rats with heat treatment/n=5; P <0.05 vs . no heat treatment). Note that no significant difference in developed muscle tension during muscle contraction was seen in control rats and PAD rats with heat treatment or without heat treatment ( P >0.05). Our data support the hypothesis that a prior heat exposure plays an inhibitory role in modifying exaggeration of the exercise pressor reflex in PAD. Support or Funding Information NIH P01 HL134609 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .