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Intensity of Voluntary Physical Exercise Affects Vesicle Development and Body Composition in an Animal Model of Endometriosis
Author(s) -
Velazquez Johnathan,
Cruz Myrella L,
Chompre Gladys,
RiveraMendez Raquel M,
Maldonado Nicmarie,
Appleyard Caroline B
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.536.3
Subject(s) - medicine , endometriosis , adipose tissue , intensity (physics) , exercise intensity , physical exercise , physiology , endocrinology , heart rate , physics , quantum mechanics , blood pressure
Endometriosis is a gynecological chronic condition caused by endometrial tissue migration outside of the uterine cavity. Some symptoms associated with this inflammatory disease are chronic pelvic pain, infertility and painful menstrual cycles. Physical activity has been shown to promote a healthy lifestyle with beneficial effects on chronic inflammatory conditions. Hypothesis Intensity of voluntary physical exercise on running wheels has an impact on body composition and will reduce vesicle development in an endometriosis animal model. Methods Endometriosis (Endo) was induced (day 0) by suturing uterine horn tissue on the intestinal mesentery of female Sprague‐Dawley rats. Our control rats (Sham) received sutures with no implants. Endo exercise rats were exposed to voluntary exercise in running wheels 14 days before surgery until day of sacrifice (day 60). Sham control and another Endo group were not exposed to exercise. Running wheel activity data (speed, distance and intensity) was collected using Scurry Activity System software. Weight change and food consumption were measured throughout the protocol. At sacrifice, vesicles were collected and measured if present. Mesenteric fat, gastrocnemius and soleus muscles were dissected, weighed and collected. Results The Endo exercise group had significantly decreased vesicle size (20.25±5.84mm 2 ) compared to the Endo no exercise group (50.27±9.48mm 2 , p<0.05). A tendency towards smaller vesicles was observed with increased exercise intensity. The Endo exercise group showed a trend towards gaining less weight, while having a significantly higher food consumption after surgery (p<0.001). The Endo no exercise group had significantly higher amounts of mesenteric fat when compared to the Sham control and Endo exercise groups (p<0.05). The muscle/fat ratio was also increased in the Endo exercise group when compared to the Endo no exercise group indicating differences were due to less presence of fat rather than differences in muscle weight following exercise. Conclusion Physical exercise ameliorates the development of vesicles and promotes decreased body fat composition in an animal model of endometriosis. The intensity of voluntary exercise appears to contribute towards the degree of impact on this condition. These results reinforce the potential beneficial effects of voluntary physical exercise as part of a daily routine to reduce endometriosis symptoms in patients. Support or Funding Information Supported in part by P20GM103475‐16 & R15AT009915 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .