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Physical Performance in Different Stages of Hypertension in Spontaneously Hypertensive Rats
Author(s) -
Campos Helton Oliveira,
Drummond Lucas Rios,
Rodrigues Quezia Teixeira,
Horta Nayara Abreu,
PrimolaGomes Thales Nicolau,
Coimbra Candido Celso
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.534.2
Subject(s) - treadmill , medicine , blood pressure , spontaneously hypertensive rat , aerobic exercise , analysis of variance , body weight , endocrinology , cardiology
The aim of study was to investigate the aerobic running performance of hypertensive rats in exercise capacity test at different ages and stages of hypertension. Male spontaneously hypertensive rat (SHR, n = 10) and normotensive wistar rats (NWR, n = 10) of 5, 8, 12 and 16 weeks were used. Experimental procedures were approved by the CEUA‐UFMG (#49/2015). Systolic blood pressure (SBP) and body mass was measured in 4 different ages. All animals were submitted to the exercise capacity test: initial speed was set to 10 m.min −1 , with increments of 1 m.min −1 every 3 min until fatigue and the inclination of treadmill was maintained at 5°. The exercise time was measured and the workload was calculated as follows: body weight (kg) x exercise time (min) x treadmill speed (m.min −1 ) x sinα (treadmill inclination) x acceleration of gravity. The hypertensive rats had lower body mass in comparison to normotensive animals at all four ages (NWR‐5: 175 ± 5 g vs . SHR‐5:119 ± 3 g; NWR‐8: 321 ± 9 g vs . SHR‐8: 233 ± 4 g; NWR‐12: 368 ± 13 g vs . SHR‐12: 264 ± 7 g; NWR‐16: 391 ± 13 g vs . SHR‐16: 324 ± 5 g; p < 0.05, two‐way ANOVA). As expected, the SHR group presented higher SBP when compared to the NWR group at all four ages (NWR‐5: 98.7 ± 3.5 mmHg vs . SHR‐5:128.8 ± 2.6 mmHg; NWR‐8: 108.1 ± 5.4 mmHg vs . SHR‐8: 169.2 ± 3.3 mmHg; NWR‐12: 112.2 ± 2.0 mmHg vs . SHR‐12: 176.5 ± 2.0 mmHg; NWR‐16: 119.8 ± 3.3 mmHg vs . SHR‐16: 195.1 ± 7.3 mmHg; p < 0.05, two‐way ANOVA). When analyzing the physical performance measured only in the exercise time, it can be observed that all the groups showed similar physical performance in all the four moments (NWR‐5: 50.6 ± 4.1 min vs . SHR‐5: 49.6 ± 2.0 min; NWR‐8: 50.0 ± 2.5 min vs . SHR‐8: 46.8 ± 2.2 min; NWR‐12: 49.8 ± 4.2 min vs . SHR‐12: 44.8 ± 1.6 min; NWR‐16: 34.5 ± 2.1 min vs . SHR‐16: 35.2 ± 1.4 min; p > 0.05, two‐way ANOVA). However, when analyzing physical running capacity was measured by workload, it can be observed that the hypertensive animals showed a lower physical performance in comparison to normotensive animals at all four ages (NWR‐5: 140 ± 17 J vs . SHR‐5: 84 ± 6 J; NWR‐8: 206 ± 18 J vs . SHR‐8: 153 ± 8 J; NWR‐12: 264 ± 29 J vs . SHR‐12: 170 ± 9 J; NWR‐16: 195 ± 13 J vs . SHR‐16: 154 ± 9 J; p < 0.05, two‐way ANOVA). In conclusion, the present results indicate that hypertensive rats exhibit reduced physical performance compared to normotensive controls, since, the most reliable index to assess physical performance when there is difference in body mass between strains is workload. Support or Funding Information FAPEMIG, CAPES and CNPq This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .