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Pre‐Transplant Medical Arterial Calcification and Post‐Transplant Hypertension
Author(s) -
Tantisattamo Ekamol,
Vutthikraivit Possawat,
Dejhansathit Siroj
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.487.23
Subject(s) - medicine , hazard ratio , kidney disease , blood pressure , kidney transplantation , cardiology , transplantation , diabetes mellitus , end stage renal disease , arterial stiffness , confidence interval , urology , hemodialysis , endocrinology
Background Medial arterial calcification (MAC) is common in chronic kidney disease (CKD) and end‐stage renal disease (ESRD). Breast arterial calcification detected by mammogram (MMG) is exclusively medial and can lead to arterial stiffness. The association between pre‐transplant MAC and hypertension (HTN) after kidney transplantation (KTx) is unknown. Method MMG performed closest to the date of KTx were examined for presence or absence of MAC. The association between MAC and systolic hypertension (SHTN) defined by systolic blood pressure (SBP) ≥130 mmHg within the first 48 weeks after KTx is examined as time‐to‐event by Cox proportional hazard analysis. Results Of all 51 kidney transplant recipients from a single kidney transplant center followed up 48 weeks after KTx, mean±SD age was 57.08±10.47 years. Ninty‐six percent of patients had pre‐transplant HTN and 41% had diabetes. Mean BP was 143.57±25.77 / 76.61±13.75 mmHg. Mean±SEM pre‐transplant SBP in patient without pre‐KTx MAC was lower than those with pre‐transplant MAC (140.74±4.65 VS. 147.95±5.73; 95% confidence interval (CI) −22.07, 7.65; p 0.3344). Compared to the patients without MAC, MAC patients had 31% greater risk of having SHTN within 48 weeks post‐KTx (HR 1.31, 95%CI 0.73, 2.37, p 0.367; Figure 1). After adjusted for age, cause of ESRD, type of KTx, type of induction immunosuppressive medications, presence or absence of pre‐KTx HTN, diabetes, BMI, DBP, and corrected calcium, the association was reversed but still not statistically significance (HR 0.72, 95%CI 0.34, 1.50, p 0.374). Conclusion Although MAC is associated with arterial stiffness in non‐transplant patients, no association between presence of pre‐transplant MAC and SHTN may indicate change in vascular stiffness. Successful KTx may modify factors effecting vascular milieu associated with MAC. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .