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The influence of neonatal intake of curcumin on expression of genes associated with lipid metabolism and inflammatory cytokines: Implication on obesity
Author(s) -
Mukwevho Emmanuel,
Matumba Mashudu Given
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.487.14
Subject(s) - curcumin , lipid metabolism , medicine , adipose tissue , obesity , diabetes mellitus , inflammation , endocrinology , metabolic syndrome , proinflammatory cytokine , overweight , type 2 diabetes , carbohydrate metabolism , pharmacology
The high prevalence of obesity is a serious global threat to the public's health and at least 41 million children younger than five years are overweight or obese, most of whom live in low‐income and middle‐income countries. Furthermore, obesity is a major risk factor for the development of type‐2 diabetes, cardiovascular disease, cancer, disability, hypertension and stroke. This current study investigated the effect of curcumin on expression of genes associated with lipid metabolism (AMPK, ACC‐1, CPT‐1, SREBP‐1, and PGC‐1) since they are known to be impaired in obesity situations. The study also investigated the effect of curcumin on inflammatory cytokines (TNF‐α, and IL‐6). This was motivated by the report indicating that obesity is associated with chronic inflammation, given evidence by the increased levels of cytokines in adipose and liver tissues. Curcumin is one the hundreds of components isolated from ancient spice turmeric and it is being studied intensively today for its potential therapeutic activity in the treatment of inflammatory diseases such as obesity, diabetes and cardiovascular diseases Therefore to achieve our aim, Sprague Dawley rats were fed with high fructose diet to induce obesity model, and the rats that developed metabolic syndrome were considered as diseased, they were then treated curcumin. Analysis of gene expression was done in liver tissues using Real‐Time PCR technique. Results clearly indicated that curcumin significantly improved all the genes associated with lipid metabolism in rats that were treated with curcumin. Furthermore, results showed significant increase on all inflammatory cytokine gene expression of rats that were induced with metabolic syndrome. These results demonstrate that curcumin produce good effects in ameliorating neonatal metabolic syndrome since it was able to downregulate all the inflammatory gene expression and improved genes associated with lipid metabolism. In conclusion, these study confirms that curcumin plays a key role on lipid metabolism and inflammatory cytokine regulation and it can be used as an effective therapeutic agent to ameliorate neonatal metabolic syndrome. Support or Funding Information Funding is from National Research Foundation (NRF) and North‐West University. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .