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Assessment of bio‐protective potentials of mistletoe leaves extract against biochemical imbalances induced by Combined Oral Contraceptives in rats
Author(s) -
Adebisi Adedayo Adebisi,
Sowunmi Tolulope,
Ogunlabi Olugbenga Owolabi,
Adegbesan Bukunola Oluyemisi
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.487.1
Subject(s) - levonorgestrel , medicine , endocrinology , lipid profile , hormone , antioxidant , cholesterol , placebo , oral administration , physiology , population , biology , biochemistry , research methodology , family planning , alternative medicine , environmental health , pathology
Combination birth control pills (Combined Oral Contraceptives ‐ COC) containing female hormones are widely used prescription medications amongst women with up to 70 million users worldwide. This study investigates the effect of prolonged administration of Combined Oral Contraceptives on some biochemical parameters in female wistar rats and the possible bio‐protective potentials of mistletoe leave extract. 30 female wistar rats were divided into three groups of 10 animals each. The groups ‐ control, group E1 and group E2, received daily oral doses of placebo, Nordette® (a COC containing Ethinyl estradiol and levonorgestrel) at 0.03mg/kg body weight and Nordette® + mistletoe leave extract at 600mg/kg body weight respectively for 21 days. Assessment of serum lipid profile, glucose level, ion element homeostasis and total antioxidant status (TAS) of animals were conducted. Our results show that the COC significantly impaired serum lipid profile (p<0.05) (increased total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and decreased HDL cholesterol), it increased serum glucose level, it increased TAS and it altered serum ion (Na + , Cl − , K + ,Ca 2+ ) levels compared to control animals. There was also a significant (P<0.05) increase in the body and uterus weight of the COC treated rats compared to the control. Co‐treatment of COC with mistletoe leaf extract however protected against these changes. The observed biochemical imbalances in the COC treated rats are common indicators of many health disorders; therefore our result suggests the bio‐protective potentials of mistletoe leaf extract against these physiological insults. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .