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Energetic and Gluconeogenic Response in Intermittent Fasting (IF)
Author(s) -
Cervantes Silvia Cristina,
Gasca Deysi,
Muñoz Mauricio Díaz
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.485.3
Subject(s) - phosphoenolpyruvate carboxykinase , gluconeogenesis , endocrinology , medicine , intermittent fasting , biology , glucose homeostasis , glucose 6 phosphatase , metabolism , carbohydrate metabolism , chemistry , enzyme , biochemistry , insulin , insulin resistance
Physiology evolved during fluctuations in energy supply and demand. Coping with these changes has entrained the organisms to manage energy metabolism for optimal substrate storage and use during feeding or fasting, and periods of either rest or energy demand. During fasting, the liver is responsible for maintaining blood glucose levels by regulating metabolic pathways, such gluconeogenesis (GNG). GNG aims to form glucose de novo, its regulation occurs due to the activity of two limiting enzymes: phosphoenolpyruvate carboxykinase (PEPCK) and glucose‐6‐phosphatase (G6Pase), and it is highly regulated (Petersen et al., 2017). The ability to efficiently adapt metabolism depending on demand or supply is known as metabolic flexibility (Smith, Soeters, Wüst, & Houtkooper, 2018). Intermittent fasting (IF) is a dietary protocol that consists of periods without access to food, alternating with periods with free access to food ( ad libitum ) (Chausse et al., 2015). The chronic regimen of the IF carries different responses to those observed in an acute fasting or continuous restriction (Secor and Carey, 2016). We evaluate the adaptation and metabolic flexibility that happened in IF to maintain homeostasis. Chronicity in IF elicit physiological and metabolic changes, such as the increase in the size of the liver after feeding to cope with total energy restriction, and increase in gluconeogenic enzymatic activity to keep normal values of glucose. Experiments of indirect calorimetry show that the values of RQ in IF on feeding conditions are restored to the first AL of the treatment until the 4th cycle of IF, which are equivalents to their pairs in the AL group. Support or Funding Information Funded by Project Conacyt 284–557 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .