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Kangxian‐Yixin shortens the duration of paroxysmal atrial fibrillation in rats
Author(s) -
Dong Lisha,
Wang Zhentao,
Chang Hongbo,
Wu Hong
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.471.4
Subject(s) - atrial fibrillation , medicine , paroxysmal atrial fibrillation , cardiology , anesthesia , fibrillation
Our aim is to observe the effects of Kangxian‐Yixin concentrated pill (KXYX) on the duration of atrial fibrillation in rats with paroxysmal atrial fibrillation. Rat models of paroxysmal atrial fibrillation were induced by tail vein injection of acetylcholine as well as calcium chloride. Fifty male Wistar rats were randomly divided into model group, propranolol group and KXYX groups in high, medium and low dose. The model group was administered of saline in equal volume, while the other groups were given the corresponding dose of medicines one time a day for 1 week. After 7 days, the rat model of paroxysmal atrial fibrillation was generated and used to record the duration of atrial fibrillation. Compared with the model group, the duration of atrial fibrillation in treatment groups were significantly shortened ( P <0.01 or P <0.05). And compared with the propranolol group, the duration in the medium‐dose and low‐dose KXYX groups were markedly longer ( P <0.01 or P <0.05). The duration in the high and medium‐dose groups were shorter than that in the low‐dose KXYX group ( P <0.01 or P <0.05). Taken together, KXYX shortens the duration of paroxysmal atrial fibrillation, suggesting that it may be a promising therapeutic medication for intervention of paroxysmal atrial fibrillation. Support or Funding Information This work was supported by grant from the National Natural Science Foundation of China (No. 81573920). This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .