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CYP 2D6* 4 polymorphism in Polycythemia vera patients in Turkish population
Author(s) -
Cifci Kezban Ucar,
Okat Zehra
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.469.5
Subject(s) - polycythemia vera , turkish population , genotype , medicine , population , polymorphism (computer science) , cyp2d6 , cytochrome p450 , gastroenterology , pharmacology , genetics , biology , gene , metabolism , environmental health
Studies have shown the association of susceptibility to several cancers with gene encoding enzymes' polymorphisms which engage in xenobiotics' biotransformation. In this study, our main motivation is to determine the relation between cytochrome P450 (CYP) 2D6* 4 polymorphisms and Polycythemia vera (PV) incidence in Turkish population. When patients and controls were compared in terms of CYP 2D6* 4 poor metabolizer (PM) and heterozygous extensive metabolizer (HEM) genotype frequency, it has been found that the patients have 1.35% PM and 32.43% HEM frequency, and controls have 2.63% PM and 21.05% HEM frequency. The correlation between the results of CYP 2D6 genotype analysis and the risk of disease in patients and controls was examined. We found that PM, HEM and extensive metabolizer (EM) genotypes were unrelated with the risk of PV (OR 0.51, 95% CI 0.04–5.71, OR 1.80, 95% CI 0.86–3.75, χ2 1.93, P: 0.164, OR 0.61, 95% CI 0.30–1.24, χ2 1.40, P: 0.235). Our results suggested that the CYP 2D6* 4 polymorphism, in the studied population, does not play an important role in PV etiology. Support or Funding Information The funding for the research came from Marmara University Scientific Research Projects Coordination Unit under the project SAG‐C‐DRP‐130515‐0162. Part of the study was published in Marmara Medical Journal in 2018. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .