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Mechanisms of Gastrulation: from Zebrafish to Human
Author(s) -
SolnicaKrezel Lila
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.14.2
Subject(s) - gastrulation , zebrafish , embryonic stem cell , germ layer , body plan , microbiology and biotechnology , biology , embryo , developmental biology , computational biology , anatomy , neuroscience , embryogenesis , genetics , gene , induced pluripotent stem cell
During animal gastrulation germ layers are induced, patterned and shaped into a body plan. These inductive and morphogenetic processes must be coordinated in space and time to ensure normal development, but the underlying mechanisms are not understood. I will discuss our forward and reverse genetic approaches in zebrafish that address this problem. I will also discuss our work with embryonic stem cells to investigate aspects of human gastrulation. Support or Funding Information 1R35GM118179‐01 NIH/NIGMS Inductive and Morphogenetic Processes Shaping the Zebrafish Embryonic Axes This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .