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Revisiting the Pharyngeal Apparatus: Arches, Pouches, & Grooves—Oh My!
Author(s) -
Dennis Jennifer
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.12.2
Subject(s) - craniofacial , anatomy , morphogenesis , biology , neural crest , skull , vertebrate , embryology , craniofacial abnormality , neuroscience , microbiology and biotechnology , embryo , biochemistry , genetics , gene
The vertebrate face is the product of growth and differentiation of structures arising from the pharyngeal apparatus. The arches, pouches, grooves, and membranes that comprise the pharyngeal apparatus undergo morphogenetic movements allowing for a typically seamless integration of tissues and cell types that orchestrate craniofacial development. The differentiation of these structures is critical for facial and skull bones, muscle, connective tissue, skin, and the central and peripheral nervous systems of the head, face, and neck to develop correctly. Hence, it is not surprising that without the proper integration of these tissues during development that craniofacial defects arise, accounting for one‐third of all congenital malformations within human populations. Of central importance, is a thorough understanding of the specific tissue interactions, movements, and fusions that occur between the craniofacial primordia in regulating craniofacial morphogenesis. In this master class, we will discuss the embryology of the head and neck, taking a holistic approach to the components of the pharyngeal apparatus, to review the various elements that come together to form the vertebrate face. Support or Funding Information None. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .