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The effects of ethanol extract of peros Punica granatum L. peel on the oxidative damage induced by diabet in rats
Author(s) -
ÖMÜR Ali Dogan,
Yıldırım Betül Dogan Apaydın
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb75
Subject(s) - punica , malondialdehyde , superoxide dismutase , glutathione peroxidase , catalase , lipid peroxidation , streptozotocin , glutathione , chemistry , antioxidant , oxidative stress , traditional medicine , pharmacology , biochemistry , diabetes mellitus , medicine , endocrinology , enzyme
This study is aimed to evaluate the effects of ethanol extract of peros Punica granatum L. peel on the oxidative damage induced by diabet in rats. In present study used twenty‐eight male Sprague–Dawley rats were randomly divided into four equal groups containing of seven rats per group. Group 1 kept as a control group, Received only vehicle 0.5 %CMC (peros), Group 2; streptozotocin group: Streptozotocin 60 mg/kg/ip single dose, Group 3; Punica granatum L peel extract (PGE) Group: PGE 10 mg/kg/20days/po, Group 4; Streptozotocin+PGE group: Streptozotocin as 60 mg/kg/ip single dose+PGE 10 mg/kg/20days/po. At the end of these processes, the animals were sacrificed, testis tissues were excised by dissection and evaluated as biochemical. Glutathione, malondialdehyde, catalase, glutathione peroxidase and superoxide dismutase were measured in the plasma and testis tissues. Punica granatum L peel extract was shown that the activity of catalase, superoxidase, glutathione peroxidase and glutathione activities increased and decreased levels of malondialdehyde in diabetic rats. As a result, the results showed that oral administration of Punica granatum L peel extract reduced the levels of lipid peroxidation and improved the antioxidant activity in plasma and testis tissues in rats treated with Punica granatum L. peel extract as compared with the diabetic and control rats. These results suggested that the Punica granatum L. peel extract enhanced the antioxidant defence under hyperglycaemic conditions hence protected the testes cells. Support or Funding Information Ataturk University This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .