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Aqueous extract of Alhagi Maurorum protects from norfloxacin‐induced hepato‐nephrotoxicity in rats
Author(s) -
Khalifa Hesham Ahmed Mohammed Ismail,
Abdelrahman Ahmed Shaban Abdelaziz,
Sahu Ravi P
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb646
Subject(s) - norfloxacin , malondialdehyde , superoxide dismutase , chemistry , pharmacology , glutathione peroxidase , antioxidant , nephrotoxicity , oxidative stress , creatinine , traditional medicine , biochemistry , antibiotics , medicine , toxicity , ciprofloxacin , organic chemistry
Objectives To determine the effects of aqueous extract of Alhagi maurorum against the adverse effects including hepato‐nephrotoxicity induced by a broad‐spectrum antibiotic norfloxacin in rats. Methods Adult male albino rats were treated with or without norfloxacin (10 mg/kg) and Alhagi maurorum (300 mg/kg). Serum samples were collected to evaluate liver and kidney function tests, and hepatic and renal tissue samples were obtained to assess antioxidant activity and histopathological examination. Results Alhagi maurorum ameliorated norfloxacin induced elevated levels of serum alkaline phosphatase (ALP), aminotransferases (AST), urea, creatinine, and uric acid. In addition, Alhagi maurorum significantly reduced the tissue levels of malondialdehyde (MDA), and increased glutathione peroxidase (GPx) and superoxide dismutase (SOD) compared to norfloxacin alone treated group. Histological analysis demonstrate that Alhagi maurorum conserved the hepatic and renal tissue damages induced by norfloxacin. Conclusion These findings indicate that Alhagi maurorum aqueous extract possesses a potent antioxidant activity and could be used to attenuate norfloxacin induced oxidative stress and hepatorenal damage in experimental models. Support or Funding Information No funding support This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .