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BMPR2 and TfR1 Interact to Each Other
Author(s) -
Alanazi Madhawi S.,
Mohildien Ashraf M.,
Nauli Surya M.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb626
Subject(s) - gene knockdown , bmpr2 , transferrin receptor , immunoprecipitation , microbiology and biotechnology , bone morphogenetic protein , biology , hek 293 cells , receptor , apoptosis , cancer research , cell culture , genetics , gene
BMPR2 (bone morphogenetic protein receptor type‐2) and TfR1 (transferrin receptor protein‐1) play an important role in embryonic development and are involved in cancer formation. Our recent proteomic study indicates that these two proteins are highly expressed in renal epithelial cells, although their functions in the kidney is not well understood. We confirm that both proteins have interaction in our immunoprecipitation study. We also knockdown BMPR2 or TfR1 expression in renal cell epithelia. Compared to scrambled control, knockdown of either BMPR2 or TfR1 results in a cell migration defect. The knockdown cells also show abnormal proliferation and apoptotic indices. In summary, our studies indicate that BMPR2 and TfR1 may share a functional interaction with each other. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .