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The Pharmacological Characterization of Riluzole on Anxiety and Memory
Author(s) -
Rossi Grace,
Rahyab Marjon,
Hindieh Jennifer,
Nuzzo Arianna,
Visquerra Vanessa,
Gelles Janine
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb613
Subject(s) - riluzole , anxiety , elevated plus maze , open field , morris water navigation task , psychology , neuroscience , medicine , hippocampus , pharmacology , clinical psychology , psychiatry , amyotrophic lateral sclerosis , disease
Riluzole is a novel medication that is presently investigated in the field of ALS research since it is a chemical that is known to promote plasticity. The present study plans to investigate the effects of Riluzole on memory in the PTSD model of anxiety in CD‐1 mice. Prior to any manipulation, all subjects were placed on an elevated plus maze (EPM) for 5 minutes in order to obtain baseline data for anxiety. After baseline data was collected, stress was induced in all animals by individually exposing to an aggressor for 5 minutes for 7–10 consecutive days. Mice were reexamined for anxiety by returning to them on the EPM. Continuing further, only anxious mice were used in the study. Twenty mice were given Riluzole (5mg/kg,i.p). All mice were tested on a spatial memory task (the Morris Water Maze) on the 10th day of exposure to the bully mouse. The goal was to investigate the effects of Riluzole on spatial memory after a fear‐provoking experience (exposure to an aggressor mice). After the 10th day of exposing the mice to aggressor mice all mice had significantly higher anxiety levels. Riluzole had limited effects on spatial memory in the anxiety mice. Empirical evidence suggests male and female's spatial memory differ. Further investigation will examine if the findings generalize to female mice as well. Support or Funding Information The present study was supported by LIU‐Post Monetary Grant. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .