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Changes in Peak Oxygen Uptake (VO 2peak ) Following Renal Transplant: Results after 3‐year Follow‐up
Author(s) -
Bushroe Cody M,
Chakkera Harini A,
Angadi Siddhartha S
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb329
Subject(s) - medicine , respiratory exchange ratio , bruce protocol , vo2 max , transplantation , renal transplant , treadmill , respiratory minute volume , cardiology , aerobic exercise , heart rate , respiratory system , blood pressure
Background Data regarding changes in markers of cardiovascular and all‐cause mortality, namely, VO 2peak and minute ventilation/carbon dioxide production (V E /VCO 2 ) slope following renal transplantation past 1‐year post‐transplant are lacking. We examined changes in VO 2peak and V E /VCO 2 before and after ~3‐years after renal transplantation. Methods Eighteen patients (age 56.2 ± 2.5 years; 82.9 ± 4.9 kg; 9 male) completed an exercise test to exhaustion using a ramp treadmill protocol. Subjects underwent pre‐transplant exercise testing (PreTx) following which they were placed on the transplant wait‐list. Average time on the waitlist was 15.6 ± 2 months. Following transplant, subjects underwent follow‐up maximal exercise testing using the same protocol (PostTx). Mean duration to post‐transplant exercise testing was 35 ± 2 months. Gas exchange data, heart rate and respiratory exchange ratios were recorded throughout exercise testing. All variables are reported as mean ± standard error. α was set at 0.05 and a paired t‐test carried out to examine changes in VO 2peak and maximal V E /VCO 2 slope before and after transplant. Results Significant reductions in relative VO 2peak were observed from PreTx = 15.2 ± 0.8 mL/kg/min to PostTX = 12.2 ± 0.4 mL/kg/min (p = 0.002 ). Also, significant increases in V e /VCO 2 were observed from PreTx = 30 ± 1.4 to PostTx = 43 ± 1.6 (p < .001). Conclusions Long term follow‐up (~3‐years) in this small cohort of patients following renal transplantation demonstrated significant reductions in VO 2peak (20%) and worsening of the V E /VCO 2 slope (30%) which are modifiable markers of mortality risk. This underscores the need for larger cohort studies to be undertaken in this population given that these markers are independently linked to cardiovascular and all‐cause mortality risk. These data may have implications for cardiovascular stratification and cardiovascular risk reduction in this population. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .