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Cerebral Autoregulation and Cerebrovascular Reactivity is Similar in African American And Caucasian Males Despite Different Blood Pressures and Anterior Cerebral Artery Flow Velocities
Author(s) -
Knox Allan,
Favre Michelle,
Haber Yaa,
Falvo Michael,
Serrador Jorge
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb323
Subject(s) - cerebral autoregulation , autoregulation , medicine , middle cerebral artery , cerebral perfusion pressure , cerebral blood flow , blood pressure , anterior cerebral artery , cardiology , anesthesia , hemodynamics , perfusion , cerebral circulation , ischemia
Cerebral autoregulation maintains adequate cerebral perfusion over varying systemic blood pressures, with any dysfunction giving opportunity for cerebral insult. African American (AA) males experience higher prevalences of hypertension and cerebrovascular abnormalities than their Caucasian (CAUC) counterparts. Potential racial differences in cerebral autoregulation may contribute to the high incidences of cerebrovascular events suffered by AA males. Therefore, the purpose of this investigation was to determine cerebral autoregulation and flow velocities of the cerebral circulation in AA and CAUC males. Cross‐sectional data of beat‐by‐beat blood pressure (BP), end‐tidal CO 2 (ETCO 2 ) middle cerebral artery (MCA) and anterior cerebral artery (ACA) velocities, cerebrovascular reactivity (CVR), and cerebral autoregulation was determined at the very low frequency (VLF: 0.03–0.07 Hz) and low frequency (LF: 0.07–0.15 Hz) domains in sample of AA (n=30, 44.91 ± 12.04 years) and CAUC (n=51, 44.48 ± 12.71 years, p =0.879) males. Mean BP was higher in AAs (96.25 ± 14.34 mmHg) than CAUCs (88.39 ± 11.93 mmHg, p =0.015). Systolic BP was elevated in AAs (137.64 ± 20.39 mmHg) compared to CAUCs (128.52 ± 16.65, p =0.037), with the same trend seen with diastolic BP (AA: 77.53 ± 12.81 mmHg; CAUC: 70.49 ± 11.31 mmHg, p =0.021). ETCO 2 and CVR was comparable between groups ( p =0.351 and p =0.290, respectively). Cerebral autoregulation was similar between groups in the MCA at the VLF (Coherence: p =0.184, Gain: p = 0.748, Phase: p =0.841) and LF (Coherence: p =0.683, Gain: p =0.800, Phase: p =0.178) domains. Cerebral autoregulation was also proportionate in the ACA at the VLF (Coherence: p =0.360, Gain: p =0.266, Phase: p =0.231) and LF (Coherence: p =0.293, Gain: p =0.530, Phase: p =0.360) domain. Autoregulation index at the MCA and ACA was comparable between groups ( p =0.358 and p =0.620, respectively). MCA mean flow velocity was similar between groups ( p =0.814), although ACA mean flow velocity was higher in AAs (52.17 ± 8.89 ml/cm/s) compared to CAUCs (44.02 ± 11.19 ml/cm/s, p =0.013). The current data demonstrate comparable levels of cerebral autoregulation in AA and CAUC males, despite differing systemic BP and ACA velocities. This proposes that cerebral autoregulation is intact within AA males and may not contribute to the increased prevalence of cerebrovascular insults shown in current epidemiological data. Future studies are warranted to include larger sample sizes in addition to absolute cerebral blood flow measures to confirm these findings. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .