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Photobiomodulation And Exercise Training Contribute To Protect The Cardiovascular System In Experimental Monoarthritis
Author(s) -
Zamuner Stella Regina,
Zamuner Luis Fernando,
Paulo Alves Silva Marcelo,
Angelis Katia,
Chavantes Maria Cristina
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb310
Subject(s) - monoarthritis , medicine , arthritis , saline , heart rate , hemodynamics , treadmill , endocrinology , cardiology , physical therapy , blood pressure
It has been shown that the inflammatory process causes autonomic changes in arthritis. This study examined the effect of non‐invasive therapies involving photobiomodulation therapy (PBMT) and exercise training (ET) on cardiovascular changes in experimental monoarthritis. Male Wistar rats (n=40) were randomly divided into five groups: sedentary control (C); arthritis (A); arthritis plus PBMT (AP); arthritis plus exercise training (AT); AP plus AT (APT). Monoarthritis was induced by intra‐articular injection of zymosan (1 mg in 50 μl of a sterile saline solution) into one rear knee joint. Moderate‐intensity training was performed on a treadmill (8 weeks/5 days a week, 40–60% maximum exercise test, 50 min/day) and PBMT was applied at 660 nm (power output 5 mW, power density 0.1 W/cm 2 , energy density 2.5 J/cm 2 , spot size 0.04 cm 2 and 20 sec irradiation time), twice a week. Evaluations of cardiac function, cardiovascular autonomic modulation, leukocyte recruitment as well as articular structure of the knee joint were measured. Ethics Committee: AN009/2014. Trained rats presented lower body weight, an increase in the maximum speed of running and lower heart rate compared to sedentary groups. Hemodynamic data showed no statistical difference among groups. In frequency domain analysis, low frequency (LF) power, indicating mainly sympathetic activity, was increased in A and AP groups, ET caused a decreased in LF power in these groups. High frequency (HF) power, indicating parasympathetic activity, was decreased in A and AP groups and ET caused an increase of HF power. The association treatment induced a reduction of LF/HF, which is associated with resting bradycardia. In addition, a better tissue organization fibers and less inflammatory cell were observed in both AP, AT and APT group, as compared to A group. In conclusion, PBMT and ET (associated or not) exert beneficial effects in arthritic rats. These benefits were related to the autonomic cardiovascular balance and the improvement of the inflammatory process in the knee joints. Support or Funding Information Grant fund: CNPq and UNINOVE This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .