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Patterns of Conduit Artery Shear Stress Across the Menopause Transition
Author(s) -
Somani Yasina B,
Moore David J,
Kim JinKwang,
Gonzales Joaquin U,
Elavsky Steriani,
Proctor David N
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb308
Subject(s) - brachial artery , menopause , medicine , cardiology , artery , postmenopausal women , femoral artery , endothelial dysfunction , endocrinology , blood pressure
Disturbed patterns of conduit artery shear, characterized by greater oscillatory (bi‐directional) and retrograde (backward) shear are associated with endothelial dysfunction. Moreover, declines in endothelial function can take place rapidly across the menopause transition, placing women at heightened risk for development of cardiovascular disease. Methods Conduit artery shear patterns were measured in women at varying stages of the menopause transition. Resting brachial artery and common femoral artery mean blood velocities and diameters were measured via Doppler ultrasound in early perimenopausal, late perimenopausal, and early postmenopausal women. Results Brachial artery oscillatory shear was significantly higher in early postmenopausal women (n=15, 0.17 ± 0.08 a.u.) than both early (n=12, 0.08 ± 0.05 a.u., p=0.002) and late (n=8, 0.08 ± 0.04 a.u., p= 0.007) perimenopausal women, and retrograde shear was significantly higher in early postmenopausal vs. early perimenopausal women (−9.74 ± 6.48 s − 1 vs. −4.81 ± 3.05 s − 1 , p= 0.03). Femoral artery retrograde and oscillatory shear were greater, respectively, in early postmenopausal women (n=15, −6.78 ± 2.91 s − 1; 0.19 ± 0.08 a.u.) than early perimenopausal women (n=14, −4.07 ± 2.21 s − 1 , p=0.03; 0.11 ± 0.08 a.u., p=0.01). Further, Pearson correlation analyses revealed significant associations between follicle stimulating hormone (FSH) and both retrograde and oscillatory shear, respectively, in the brachial (R=−0.37, p=0.04; R=0.5, p=0.005) and common femoral artery (R=−0.4, p=0.03; R=0.45, p=0.01). Discussion Our findings suggest that increases to conduit artery retrograde and oscillatory shear take place during the menopause transition and these increases are associated with FSH, a marker of reproductive age. Support or Funding Information Social Sciences Research Institute and Center on Population Health and Aging at Penn State, M01 RR‐10732 (General Clinical Research Center), K12 HD055882 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .