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Ventricular activation times in rainbow trout and common carp
Author(s) -
Vaikshnoraite Marina Alvirasovna,
Azarov Jan
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb232
Subject(s) - rainbow trout , cyprinus , common carp , qrs complex , anatomy , interquartile range , fish <actinopterygii> , cardiology , medicine , zoology , chemistry , biology , fishery
The specific objective of the present study was to find out the presence or absence of a transmural gradient of ventricular activation times in fish having pyramidal and sac‐like hearts, which in turn have relatively pronounced and negligible amount of the compact type of myocardium, respectively. Experiments were done in rainbow trout (Onchorhynchus mykiss, n=6; body weight 320–510 g) and common carp (Cyprinus carpio, n=6; body weight 900–1300 g) presenting fish species with the pyramidal (pronounced compact layer) and sac‐like (negligible compact layer) heart types. The investigation was carried out in accordance with the Guide for the Care and Use of Laboratory Animals, 8th Edition published by the National Academies Press (US) 2011. Body surface ECG was recorded in the longitudinal body axis lead. Ventricular unipolar electrograms were recorded from the ventricular walls as described earlier (Vaykshnorayte et al., 2011). In each ventricular lead, activation time were determined as instants of dV/dt minimum during QRS complex (Coronel et al., 2006). Data are expressed as medians and interquartile intervals. Statistical analysis was performed with SPSS package (IBM SPSS Statistics 23, SPSS, Inc., Chicago, Illinois, USA). Common carps demonstrated significantly longer QRS complex in comparison with rainbow trout (79 (IQR 72–85); 56 (IQR 48–61), P<0.05), whereas a difference in RR interval was statistically insignificant (1892 (IQR 1609–2074); 1470 (IQR 970–2175), P>0.05). The gross activation sequence in both species was similar and demonstrated a direction from atrioventricular junction to apex and anterior base (apicobasal activation gradient, P <0.005). The transmural activation pattern was also similar in the studied animals with the activation spread direction from endocardium to epicardium in all parts of the myocardium (transmural activation gradient, P <0.005). In this way, It implies that a transmural activation pattern do not have differences in hearts with different spongy/compact percentage of the ventricular wall in these fish species. Support or Funding Information This work was supported by the Ural Branch of the Russian Academy of Sciences (AAAA‐A18‐ 118012290365‐2) and the Program for Fundamental Research of RAS (AAAA‐A17‐ 117012310154‐6). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .