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Biomedical Status of Women Attending In‐Vitro Fertilization Clinics in Nigeria
Author(s) -
Gbenle Oluwasegun Adekunle,
IgwoEzikpe Miriam N.,
Taiwo Idowu A.,
Anyashina Olumuyiwa A.,
Ofoma Osita N.,
Ikwuazom Okwunna O.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb162
Subject(s) - luteinizing hormone , infertility , hormone , prolactin , physiology , follicle stimulating hormone , medicine , in vitro fertilisation , reproductive medicine , fertility , gynecology , andrology , endocrinology , biology , pregnancy , population , genetics , environmental health
Infertility constitutes a major problem in many developing countries like Nigeria where itsprevalence is significant. The relationship between the endocrinological, physiological and environmental determinants of conception in IVF among Nigerian infertile women have not been well elucidated; hence, the need for the biomedical status of women attending IVF Clinics in Nigeria. Blood samples of infertile women (n=200) undergoing in‐vitro fertilization were obtained from different fertility clinics in Nigeria. Questionnaires were distributed to participants to obtain physiological characteristics such as age, blood group, genotype and Rhesus factor. The levels of reproductive hormones (Luteinizing Hormone, Follicle Stimulating Hormone and Prolactin) were analysed using a micro‐plate reader while the levels of heavy metals (Mercury, Lead, Cadmium and Chromium) in the blood samples was determined using atomic absorption spectroscopy. There was significant (p< 0.05) difference in the levels of Luteinizing Hormone, Follicle Stimulating Hormone and Prolactin between the age groups of the infertile women. There was higher non significant (p>0.05) levels of the three reproductive hormones in the negative Rhesus factor subjects compared to positive Rhesus factor. However, there was no significant (p<0.5) difference in the three reproductive hormones in relation to the blood grouped subjects. There was significant (p<0.5) difference between the levels of the reproductive hormones and age. There were more negative correlations between the levels of reproductive hormones and levels of heavy metals whereas there was no significantdifference between the levels of heavy metals and age of infertile women. The study suggests that IVF patients with a specific blood group do not have a higher incidence of reduced fertility in response to ovarian stimulation. It also suggests no relationship between Rhesus factor and infertility but age and levels of heavy metals may affect female infertility. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .