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EFFECT OF DELTAMETHRIN ON THE FRAGILITY OF RED BLOOD CELLS IN ALBINO RATS
Author(s) -
Umunnakwe Shalom E.,
Chidi Nosiri,
Friday Uhegbu
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.lb160
Subject(s) - deltamethrin , erythrocyte fragility , mean corpuscular volume , mean corpuscular hemoglobin concentration , hemoglobin , mean corpuscular hemoglobin , red blood cell , toxicology , chemistry , andrology , zoology , biology , medicine , immunology , biochemistry , pesticide , hemolysis , ecology
This study investigated the toxic effect of Deltamethrin dust Insecticide on the fragility of red blood cells using albino rats. Deltamethrin is an insecticide belonging to the Pyrethroid family used to kill bed bugs, ticks, fleas and spiders. In this study animals were divided into four groups: the test group1 as the control, group II recieved 0.03ml of the insecticide, groups III and IV recieved 0.05ml and 0.08ml of the insecticide respectively. The results showed a slight decrease in packed cell volume (PCV), Heamoglobin (Hb), and Red Blood Cell (RBC) concentrations with the values thus: PCV (40.80 +2.94% to 36.94±0.20%), HB (13.60±0.98g/dl to 12.31±0.06g/dl) and RBC concentration from 5.80±0.20 to 5.33±0.12(x1012 mm3). For Mean corpuscular volume (MCV) and Mean Corpuscular Hemoglobin (MCH) they experienced slight increase from 68.79±4.72 to 69.38±1.32(fl) and 22.87±1.32 to 23.13 ±0.44(pg) respectively. The Mean Corpuscular Heamoglobin Concentration (MCHC) had a constant value at 33.33g/dl. Oxidative stress from environmental toxicants like Deltamethrin dust insecticide may have affected the membrane intergrity of the RBC by the membrane shrinking or hemolysing showing that osmotic fragility has taken place in the animals used. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .