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Nighttime sodium intake is associated with cardiometabolic risk and insulin resistance in night shift nurses
Author(s) -
Speed Joshua S.,
Molzov Hylton E.,
Johnson Russell L.,
Becker Bryan K.,
Pollock David M.,
Gamble Karen L.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.906.11
Subject(s) - shift work , insulin resistance , medicine , night work , circadian rhythm , endocrinology , insulin , zoology , biology , psychiatry
Night shift work and salt intake are each independent risk factors for cardiovascular disease and possibly insulin resistance. Rhythms in renal sodium excretory function are observed regardless of the time of intake suggesting that salt ingested during the typical inactive period is retained until the following active period. Thus, we hypothesized that eating more salt at night contributes to cardiometabolic disease risk in night shift workers. Day and night shift nurses were followed for 8 days total (5 days off work and 3 days on work) keeping strict food diaries. Nutrient intake was estimated using the Nutrition Data System for Research. Fasting blood draws were taken on day 9. Interestingly, 24‐hour Na + intake was similar between day and night shift workers throughout the observation period. Both day and night shift workers had similar Na + intake patterns during off days. As expected, night shift workers consumed significantly more Na + during the night while day shift workers consumed significantly more Na + during the day on workdays. The major finding of the study is that greater work‐night Na + intake was a significant predictor of elevated homeostatic model assessment ‐ insulin resistance (HOMA‐IR), a measure of insulin resistance, for night‐shift nurses only, even after controlling for the effect of work‐night caloric intake (F(1,5)Δ = 16.4, p < 0.05; b = 0.84). In addition, nighttime Na + intake accounted for 71% of the variance in HOMA‐IR in night shift nurses. Finally, a significant positive correlation was observed between nighttime Na + intake and fasting total cholesterol (p<0.05, r 2 =0.57) and triglycerides (p<0.05, r 2 =0.66) in night shift nurses. These data suggest that lowering nighttime salt intake in night shift workers may improve cardiometabolic risk and insulin resistance in this population with a high prevalence of cardiovascular disease. Support or Funding Information This research was supported by NIH grant K99HL127178 to JSS, the UAB Center for Clinical and Translational Science (CCTS) Grant Number ULITR000165 to KLG, the UAB Department of Vision Sciences, the UAB Comprehensive Diabetes Center, and the UAB Department of Psychiatry Office of Clinical Research This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .