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Association between cardio‐metabolic risk factors, plasma catecholamines and cognitive performance in Mexican pre‐adolescents
Author(s) -
SotoPiña Alexandra Estela,
FloresReséndiz Constantino,
ValdésRamos Roxana,
BenítezArciniega Alejandra Donají,
MartínezCarrillo Beatriz
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.906.10
Subject(s) - medicine , endocrinology , very low density lipoprotein , cholesterol , epinephrine , obesity , cognition , executive functions , lipoprotein , psychology , risk factor , high density lipoprotein , psychiatry
Cardiovascular and metabolic syndrome (MS) risk factors are associated with the generation of vascular cognitive impairment and aging. Dislipidemia and obesity are two of the main factors that promote cognitive decline because of the accumulation of fat in vascular tissue and neuroendocrine disruption. In order to prevent the development of these alterations into chronic diseases, it is important to identify and correct them at earlier life stages. The hypothesis of this study was that metabolic risk factors and sympathoadrenal alterations in pre‐adolescents are associated with cognitive dysfunction. Our aim was to determine whether there is a correlation between cardio‐metabolic risk factors, plasma catecholamines as well as memory, attention and executive functions. We performed a cross‐sectional study where 139 pre‐adolescents 10–14 years old were involved. Memory, attention and executive functions were evaluated using Neuropsi test. Blood concentrations of Triacylglycerols (TG), cholesterol, low density lipoprotein‐cholesterol (LDL‐c), very low lipoprotein‐cholesterol (VLDL‐C), high density lipoprotein cholesterol (HDL‐C) and plasma catecholamines were measured as well. Pearson correlation and multivariate regression analyses were performed to find a relation between these variables. We found that TG and VLDL‐C were negatively related to memory (−0.19 and −0.19, respectively; * p <0.05,). Multivariate regression analysis for memory and executive functions showed that each one has a negative relation with HDL‐c (B= −1.12 and −0.8, respectively; * p <0.05). Moreover, plasma epinephrine was inversely related to executive functions (B=−0–05; * p <0.05). Therefore, elevations of LDL‐c, TG and epinephrine as well as low HDL‐c blood concentrations can alter cognitive performance during pre‐adolescence. Support or Funding Information This investigation was supported by grants 3838/2014FSH and 3561/2015PIC from Universidad Autónoma del Estado de México. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .