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Immune Function In The Basoendothermic Common Tenrec, Tenrec ecaudatus
Author(s) -
Smith Catlene J.,
Breukelen Frank
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.861.8
Subject(s) - torpor , hibernation (computing) , immune system , lipopolysaccharide , biology , physiology , thermoregulation , zoology , immunology , endocrinology , state (computer science) , algorithm , computer science
Common tenrecs, Tenrec ecaudatus, are small hibernating mammals endemic to Madagascar and demonstrate extreme variability in body temperature and metabolism. When housed at ambient temperatures of 12–28 °C, tenrecs may hibernate or be active with body temperatures of ~13–34 °C depending on ambient temperature. During hibernation, tenrecs are consistently lethargic and do not exhibit the typical euthermic periods of rewarming that other hibernators experience. In classic hibernators, injection of lipopolysaccharide (LPS) during torpor results in an elevated temperature during the subsequent periodic arousal between torpor bouts. In tenrecs, injection of LPS does not result in increased temperature suggesting no immune recognition of LPS. Complement activity in tenrecs will be determined through the ability to lyse foreign red blood cells to determine the status of immune function in various states and as a function of body temperature. These data will help define the immune status across the annual cycle in a mammal with ancestral features. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .