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The Status Of Protein Translation In A Metabolically Flexible Mammal, The Common Tenrec, Tenrec ecaudatus
Author(s) -
Wilson Jared Nicholas,
Breukelen Frank
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.861.4
Subject(s) - torpor , hibernation (computing) , biology , zoology , physiology , ecology , thermoregulation , state (computer science) , algorithm , computer science
Common tenrecs, Tenrec ecaudatus , are small tropical hibernating mammals endemic to Madagascar. Tenrecs possess many phenotypic features associated to ancestral mammals, suggesting they may act as a model of an ancestral form of hibernation. Common tenrecs are able to hibernate at ambient temperatures ranging from 12 to 28 °C and do not undergo brief periodic returns to euthermy during the hibernation season, a shared feature among all other known hibernators. Tenrecs display extreme metabolic flexibility. For instance, they can spontaneously enter torpor during the active season, termed facultative torpor (FT). During both hibernation and FT, oxygen consumption rates have been observed to be 1–14% of active rates depending on ambient temperatures. Protein metabolism may account for 30% or more of standard oxygen consumption rates for most animals. Polysome profiles were used to determine the status of translation in tenrecs as a function of core body temperature (Tb) and activity state. Our findings will provide mechanistic data that will be used to elucidate how common tenrecs are able to regulate metabolic flux exclusive of Tb. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .