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Sarcopenia‐Associated Plasma Biochemistry of Community‐Based Women Enrolled in a Lifestyle Modification Program
Author(s) -
Barros Layene Peixoto,
Kano Hugo Tadashi,
Manda Rodrigo Minoru,
Bernardino Caroline,
Nakagaki Mariana Santoro,
Burini Roberto Carlos
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.856.3
Subject(s) - sarcopenia , quartile , socioeconomic status , medicine , anthropometry , body mass index , muscle mass , uric acid , gerontology , endocrinology , demography , physiology , environmental health , population , confidence interval , sociology
RATIONALE Sarcopenia is one of major currently illness associated with contemporary behaviors and having metabolic outcomes yet to be clarified. PURPOSE This study aimed to identify demographic, socioeconomic, physical activity and particularly clinical‐biochemical factors associated with muscle mass hypotrophy in community‐based women screened for a lifestyle modification program. METHODS Baseline data were analysed from 996 women (55.7 ± 15.9 years old), clinically selected for the “Move for Health” lifestyle modification program during 2005 to 2016. The cross‐sectional analysis had muscle mass as independent variable and the co‐variables demographic, socioeconomic, physical activity, anthropometry, and biochemical data. Muscular Mass Index (kg muscle mass/m 2 height =MMI) data was splitted into quartiles for the co‐variables distribution and analysis by Statistica 10.0 software, with p <0.05 as significant. RESULTS Women with lower muscle mass (Q1) were older, with incomplete elementary education, low family income, presenting poor perception of health status and classified at the lowest level of weekly physical activity. The lower muscle mass was accompanied by higher values of TG, hs‐CRP, fasting glucose and HOMA‐IR, and lower values of HDL‐col, uric acid, albumin and leukocytes. By 92% of Q1 could be attained by the plasma variables HDL‐col, HOMA‐IR and hs‐CRP, in descending order of magnitude. CONCLUSION Muscle hypotrophy of adult female is associated with increased inflammatory and pro‐oxidant markers, characteristics of aging, lower socioeconomic status and low physical activity levels. Support or Funding Information Supported by CNPq and CAPES This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .