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Respiratory Muscle Training Positively Affects Vasomotor Response in Young Healthy Women
Author(s) -
Esposito Fabio,
Bisconti Angela Valentina,
Devoto Michela,
Venturelli Massimo,
Bryner Randall,
Olfert Mark Ivan,
Chantler Paul
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.855.12
Subject(s) - vasomotor , medicine , hyperventilation , heart rate , heart rate variability , cardiology , vasodilation , brachial artery , blood pressure , anesthesia
Vasomotor response is related to the capacity of the vessel to maintain the homeostasis of the vascular tone. Two main control mechanisms are involved: the autonomic control of the sympathetic neural drive (global control) and the endothelial smooth cells capacity to respond to mechanical stress by releasing vasoactive factors (local control). The aim of the study was to evaluate the effects of respiratory muscle training (RMT) on vasomotor response, assessed by flow‐mediated dilation and heart rate variability, in young healthy females. The hypothesis was that RMT may enhance the balance between sympathetic and parasympathetic neural drive and reduce vessels shear stress. To this purpose, twenty‐four women were assigned randomly to RMT or SHAM group. Maximal inspiratory mouth pressure and maximum voluntary ventilation were utilized to assess the effectiveness of the RMT program, which consisted of three sessions of isocapnic hyperventilation per week, eight weeks, for a total of twenty‐four training sessions. Heart rate variability was utilized to evaluate the autonomic balance, a global factor regulating vasomotor response. Endothelial function was determined by measuring brachial artery vasodilation normalized by the shear rate (%FMD/SR). After RMT, maximal inspiratory mouth pressure and maximum voluntary ventilation increased significantly (+31% and +16%, respectively) only in RMT. Changes in heart rate variability were negligible in both groups. Only RMT exhibited a significant increase in endothelial function (%FMD/SR +45%; p<0.05). These data indicate a positive effect of RMT on vasomotor response likely via a reduction in shear stress in the vessels, and not through a modulation of sympatho‐vagal balance. Support or Funding Information Grant from the Department of Biomedical Sciences for Health, Università degli Studi di Milano. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .