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Acute Sildenafil Treatment Improves Exercise Capacity in Patients with Cystic Fibrosis
Author(s) -
Gonzalez Vincent,
Siegler Nichole,
Crandall Reva,
Mckie Kathleen T.,
Forseen Caralee,
RodriguezMiguelez Paula,
Tucker Matthew,
Harris Ryan A.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.853.5
Subject(s) - sildenafil , medicine , placebo , cgmp specific phosphodiesterase type 5 , cystic fibrosis , heart rate , cardiology , exercise intolerance , blood pressure , heart failure , alternative medicine , pathology
Background Exercise capacity has been shown to predict quality of life, mortality, and risk for hospitalization in patients with Cystic Fibrosis (CF). Many patients with CF exhibit exercise intolerance, the mechanism of which has yet to be elucidated. Sildenafil, a phosphodiesterase type 5 inhibitor, increases blood flow and therefore may improve exercise capacity in patients with CF. Purpose The purpose of this study was to determine whether an acute dose of sildenafil improves exercise capacity in patients with CF. Methods 13 patients with CF (mean age = 25 ± 10 years) participated in a double blind, randomized, placebo controlled study. Exercise capacity utilizing the Godfrey Protocol on a cycle ergometer was assessed at baseline and 1 hour following treatment with either sildenafil (50 mg) or placebo. Results A significantly greater increase (p = 0.024) in VO 2 peak was observed following sildenafil treatment (4.16 ± 1.54 ml/kg/FFM) compared to placebo (1.09 ± 1.31 ml/kg/FFM). The change in maximal heart rate during exercise was statistically (p = 0.007) greater following sildenafil treatment (6.07 ± 4.04 bpm) compared to placebo (−1.54 ± 6.06 bpm). The change in chronotropic index (CRI) was significantly (p = 0.006) higher following sildenafil treatment (0.08 ± 0.02) compared with placebo (0.04 ± 0.02). Conclusion/Interpretation These findings suggest that an acute dose of sildenafil improves exercise capacity in patients with CF. In addition, treatment with sildenafil improved CRI. Future studies should focus on elucidating the mechanisms for improvement in exercise capacity and CRI as both are predictors of mortality. Support or Funding Information Supported in part by the Medical College of Georgia's Medical Scholar Program and the Laboratory of Integrative Vascular and Exercise Physiology. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .