Premium
Non‐invasive Multiparametric MRI of the Kidneys
Author(s) -
Eckerbom Per,
Hansell Peter,
Cox Eleanor,
Buchanan Charlotte,
Weis Jan,
Palm Fredrik,
Francis Susan,
Liss Per
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.851.8
Subject(s) - medicine , nuclear medicine , perfusion , diffusion mri , kidney , effective diffusion coefficient , magnetic resonance imaging , perfusion scanning , urology , radiology
MRI can provide information of renal physiological parameters in a safe, non‐invasive and relatively fast way. In this study we determined baseline values for total (tRBF) and regional (rRBF) renal blood flow, regional oxygenation level (R2*), regional true (D) and apparent (ADC) diffusion and regional T 1 in healthy volunteers using the MRI techniques of Phase Contrast (PC), Arterial Spin Labeling (ASL), Blood Oxygen Level Dependent R2* (BOLD), Diffusion Weighted Imaging (DWI) and T 1 . Measurements of ADC and T 1 are of interest since they have been shown to correlate to the degree of fibrosis. 28 healthy volunteers (15 female, 13 male) were recruited and underwent a 3T MRI scan. Since no significant differences of the investigated biomarkers were found between the corresponding regions in the left and right kidney or between the genders, only mean values are presented. Average tRBF through the kidney was 503±138 ml/min and global perfusion was 312±87 ml/min/100 g. Good correlations were found between tRBF and body surface area, BMI, and kidney volume. For cortex, outer and inner medulla, rRBF values, measured by ASL, were 290±63, 91±14 and 42±16 ml/min/100 g, resp, R 2 * values (BOLD) were 16.5±1.1, 26.8±1.6, and 36.8±3.8 s −1 resp, ADC values (DWI) were 2.43±0.17, 2.14±0.19 and 2.01±0.19 ×10 −3 mm 2 /s resp, D values (DWI) were 2.11±0.23, 1.86±0.18 and 1.71±0.20 ×10 −3 mm 2 /s resp and T 1 values were 1146±76, 1403±170, and 1512±205 ms, resp. Significant interregional differences were found between cortex, outer and inner medulla in all studied parameters. In conclusion, MRI provides reliable and robust biomarkers for assessment of kidney function in an acceptable acquisition time. Knowledge of normal values of such functional biomarkers in different regions of the kidney is inevitable before their use in research or in clinical practice.Correlation between tRBF and Body Surface Area, BMI and Kidney volumeROI positions for ASL, BOLD, DWI and T 1This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .