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Curcumin Attenuates Expression of Adhesion Molecules by IL‐1 β in HUVECs
Author(s) -
Chang WengCheng,
Yu YaMei,
Cheng AnChin
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.837.5
Subject(s) - curcumin , cell adhesion molecule , e selectin , cell adhesion , vcam 1 , endothelium , umbilical vein , chemistry , u937 cell , pharmacology , biochemistry , in vitro , microbiology and biotechnology , biology , icam 1 , cell , endocrinology
Atherosclerosis, a progressive pathological disorder inducing cardiovascular and cerebrovascular diseases, is a leading cause of human morbidity and mortality worldwide. The expression of cell adhesion molecules such as intercellular adhesion molecule (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and adhesion molecule‐1 (E‐selectin) by the endothelium and the attachment of monocytes to endothelium may play a pivotal role in the early atherogenic process. Curcumin is a polyphenol obtained from the root of the turmeric (Curcuma longa), and is the main component of curry powder for giving a specific flavor and yellow color. Previous studies indicated that curcumin exhibits a variety of pharmacological effects including anti‐inflammatory, antitumor, antioxidant, anti‐hypertensive, antiviral, anti‐obesity, anti‐infectious activities and wound‐healing properties. In this study, efforts were made to identify curcumin may aid in the prevention of monocyte‐endothelial cell adhesion induced atherosclerosis. Our results indicated that curcumin could inhibit the expression of adhesion molecules, including ICAM‐1, VCAM‐1, and E‐selectin, and futher decrease the adhesiveness to a human monocytic cell line (U937) in human umbilical vein endothelial cells (HUVECs). These results demonstrated that curcumin has inhibitory effect on proanthersclerotic mechanism in vitro. Support or Funding Information This study was supported by NSC 100‐2313‐B‐309‐003 to A‐C Cheng and NSC 95‐2815‐C‐039‐019‐B to Y‐M Yu. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .