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Metabolic plasticity through pregnancy with normal pregestational BMI
Author(s) -
DelgadilloVelazquez Jaime,
PatiñoGonzalez Nayeli,
NamboVenegas Rafael,
MillánCortés Alexis,
VadilloOrtega Felipe,
PalaciosGonzalez Berenice
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.767.13
Subject(s) - postprandial , pregnancy , insulin resistance , medicine , metabolic syndrome , endocrinology , fetus , gestational diabetes , respiratory quotient , physiology , obstetrics , insulin , gestation , obesity , biology , genetics
During normal pregnancy, metabolic changes occur causing weight gain and insulin resistance to provide the fetus with substrates for growth and development. Hence, a metabolic plasticity must exist to allow the mother to adapt correctly upon the pregnancy metabolic overload, preventing adverse outcomes like gestational diabetes. The aim of the study was to analyze the metabolic plasticity during pregnancy in women with normal pregestational BMI. Glucose, triglycerides and total cholesterol were determined, and indirect calorimetry was performed during fasting and after the consumption of a high‐carbohydrate meal. Fasting triglycerides and total cholesterol were significantly higher during the third trimester. Postprandial glucose concentrations were significantly lower at second trimester and higher in third trimester compared to first trimester. There was a significant increase in fasting respiratory quotient (RQ) during the last trimester compared to the first and second trimester. Regarding ΔRQ, there was a significant decrease during the last trimester compared to the first trimester. In conclusion, at the end of pregnancy there is a lower metabolic flexibility, associated with the presence of physiological insulin resistance. Support or Funding Information This study was funded by CONACYT grant FOSISS 2016 # 273110 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .