Premium
Effects Of Dates (Phoenix Dactylifera L.) On Basal And Stimulated Gastric Acid Secretion Due To Histamine, Pentagastrin And Carbachol In Rats
Author(s) -
Onwuchekwa Chinedu,
Okon Bassey
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.759.5
Subject(s) - pentagastrin , carbachol , histamine , basal (medicine) , gastric acid , phoenix dactylifera , medicine , endocrinology , chemistry , pharmacology , secretion , stimulation , palm , physics , quantum mechanics , insulin
Local folk claims that dates (Phoenix dactylifera L.) has a gastric beneficial role in humans. This study was carried out to examine the effects of dates on basal and stimulated gastric acid secretion (GAS) in the Wistar rats. Each group of rats consisting of 6 rats (180 – 210 g) were treated with aqueous undialyzed extract of dates (1.5 mg/kg, 2.5 mg/kg and 4 mg/kg) orally for 21 days. At the last day of the treatment, the rats were fasted for 24 hours, anaesthetised with ketamine. GAS ( mEq/l) induced by histamine, pentagastrin and carbachol administration were assessed by the continuous perfusion technique. Data were analysed using student's t‐test and ANOVA at p= 0.05. The aqueous extract of undialyzed dates significantly decreased (p<0.05) GAS induced by the histamine, pentagastrin and carbachol in a dose‐ dependent manner over 80 minute's period in all the treated groups. The gastroprotective action of dates may be multifactorial and this may include an anti‐secretory action. Support or Funding Information Usmanu Danfodiyo University, Sokoto Nigeria This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .