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EFFECTS OF AEROBIC EXERCISE ON ISOPROTERENOL‐INDUCED CARDIAC DAMAGED RATS ASSOCIATED WITH BRAIN FUNCTIONS
Author(s) -
Toth Kata,
Nyakas Csaba,
Zee Eddy A.,
Schoemaker Regien G.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.740.5
Subject(s) - neuroinflammation , medicine , ejection fraction , agonist , cardiac function curve , aerobic exercise , cardiology , saline , myocardial infarction , endocrinology , microglia , open field , receptor , heart failure , inflammation
Background A bidirectional relationship was found between myocardial infarction (MI) and depression in patients, while comorbidity worsens prognosis. Alterations in neuroimmune processes are suspected to play a role in this interaction. Exercise has been shown to be beneficial for both conditions separately. Moreover, exercise has been indicated to have anti‐inflammatory effects. Aim of this study is to investigate whether isoproterenol‐induced cardiac damage is leading to neuroinflammation, behavioral and cognitive changes; and whether exercise can affect these parameters. Methods Female Wistar rats (11 months) were injected with either isoproterenol hydrochloride (ISO); a nonselective beta‐adrenoceptor agonist (70 mg/kg) or saline s.c. on two consecutive days, and allowed to recover for 2 weeks. Then groups were divided into sedentary and exercise subgroups, the latter undergoing 4 weeks of moderate intensity treadmill running. Cardiac function was assessed with echocardiography. Depressive‐like behavior was measured by open field (OF), while cognitive function was obtained from novel location (NL) and novel object (NO) recognition tests. Neuroinflammation was examined immunohistochemically by microglia activation, calculated as cell body to cell size ratio in IBA‐1 stained sections. Results Cardiac dysfunction after ISO injection was confirmed by lower ejection fraction (EF; 72±1% in ISO vs 76±1% in saline rats), with no significant effect of exercise. Exercise tended to decrease depressive‐like behavior in the OF (% time in center: sedentary 7.8±1.8%; runners 13.1±1.9%; p=0.065). No significant effect of ISO on cognitive performance could be observed. ISO significantly decreased microglia activity by increasing dendrite area at similar cell body area (cell body/cell size 6.0±0.4 vs 7.6±0.4%) in the hippocampus CA1 area. Exercise had no significant effect on cognition or microglia morphology. Conclusions Cardiac dysfunction after repeated ISO injection in female rats reduced hippocampal microglial activation by increasing dendrite area. This may indicate alternative activation, associated with tissue protective properties. However, these immune changes were not associated with differences in behavior. Continuous aerobic exercise may increase exploration of the center of the OF, suggesting reduced anxiety. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .