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Influence of Liposome Encapsulated Vitamin C on the Cardiac Autonomic Response To A High‐Calorie Meal
Author(s) -
Bell Christopher,
Hanson Moriah Ruth,
Fleck Joshua Robert,
Grimm Nathan Carlisle
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.731.6
Subject(s) - ingestion , meal , vitamin c , placebo , medicine , vitamin , endocrinology , calorie , blood pressure , heart rate , liposome , chemistry , biochemistry , alternative medicine , pathology
Oxidative stress is adversely associated with heart rate variability and may be favorably modified with ingestion of antioxidants. The purpose of this study was to determine if prior ingestion of liposome encapsulated vitamin C favorably modifies the cardiac autonomic response to a high‐calorie meal. Ten young healthy adults (age: 26 ± 2 years, body mass index: 24.0 ± 1.4 kg/m 2 ; blood pressure: 113/68 ± 3/2 mmHg; mean ± SE) ingested either a placebo or 5 g of liposome encapsulated vitamin C. Two hours later, they ingested a high‐calorie liquid meal (979 kcal; 30% fat, 64% carbohydrate, 6% protein). Circulating vitamin C concentrations, blood pressure and heart rate variability were measured over 6‐hours. Compared with placebo (0.7 ± 0.1 mg/dL), liposome encapsulated vitamin C ingestion appreciably increased circulating vitamin C (peak: 3.3 ± 0.1 mg/dL; P<0.01); concentrations remained high at 6‐hours (2.0 ± 0.1 mg/dL). Systolic blood pressure was increased following the meal however the magnitude of increase was lower with prior liposome encapsulated vitamin C (time × treatment interaction: P =0.019). Heart rate variability (standard deviation of R‐to‐R interval) was greater in the placebo compared with liposome encapsulated vitamin C (main effect: 104 ± 3 vs . 94 ± 3 ms; P =0.04) and decreased 1‐hour after the meal (main effect: 102 ± 5 vs . 87±5 ms; P =0.02); liposome encapsulated vitamin C did not influence this response ( P =0.563). Similarly, the LF/HF ratio was greater with liposome encapsulated vitamin C compared with placebo (main effect: 7.3 ± 1.4 vs . 12.0 ± 1.4; P =0.041). Liposome encapsulated vitamin C appreciably increased circulating vitamin C concentration, favorably modified the systolic blood pressure response to a high‐calorie meal while potentially unfavorably modifying the heart rate variability response. Support or Funding Information Empirical Labs This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .