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Impact of Aerobic Capacity, Age and Duration of Disease on Arterial Function in Individuals with Multiple Sclerosis
Author(s) -
Hibner Brooks A.,
Griffith Garett,
Schroeder Elizabeth C.,
Rosenberg Alexander J.,
Hilgenkamp Thessa I.M.,
Bollaert Rachel E.,
Motl Robert W.,
Baynard Tracy,
Fernhall Bo
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.722.28
Subject(s) - medicine , arterial stiffness , cardiology , reactive hyperemia , blood pressure , plethysmograph , vascular resistance , aerobic exercise , isometric exercise , cohort , vasodilation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system associated with vascular dysfunction and increased risk of cardiovascular disease and mortality. Aerobic capacity (VO 2peak ) and age are strong predictors of arterial function in a healthy cohort; however, we know very little about the role of VO 2peak , disease duration, and age on vasculature in those with MS. Purpose To evaluate the role of fitness, duration of disease since diagnosis (Dx) and age on arterial function in individuals with MS. Methods 56 individuals (Male: 15, 46±12 yrs, BMI: 29.0±6.8) with MS were divided into young (≤50 years) or older (>50 years) groups. The age groups were further delineated by length of Dx, defined as short (≤10 years) or long (>10 years). Brachial blood pressure (BP) was obtained after a 10 minute rest. Resistance artery function was assessed using strain gauge plethysmography. Reactive hyperemia was calculated as the absolute change between resting and peak flow. Carotid artery stiffness was assessed by ultrasound (Beta‐Stiffness Index (β), Elastic Modulus (Ep) and Arterial Compliance (AC)). A maximal incremental cycle test was performed to assess VO 2peak . Results See Table. Older adults with MS had higher systolic and mean BP (p<0.05). Length of Dx and age did not influence resistance vessel function (p>0.05), however, VO2peak was associated with peak forearm blood flow and peak conductance. Young and older adults with MS exhibited differential responses in large artery stiffness with disease progression, even after controlling for fitness level (β, Ep, AC) (interactions, p<0.05). Older adults had higher arterial stiffness (β, Ep, AC) with shorter disease duration compared to young. However, with longer disease duration, there was no difference between younger and older adults (p>0.05). β and Ep in older adults decreased with progression of MS (p<0.05). Disease duration did not affect arterial stiffness in young adults (p>0.05). Conclusion It appears greater fitness can improve resistance artery function in the MS population. Fitness does not influence large artery stiffness in MS, but with age and duration of disease β and Ep are counterintuitively reduced. These findings require further investigation to elucidate the effects of age, VO 2peak and length of Dx on vascular function in MS. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .