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The Effects of Sex and Histamine Receptor Blockade on Carotid Wave Intensity Before and After Exercise
Author(s) -
Melendez Rosado Keyshla Marie,
Yan Huimin
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.722.13
Subject(s) - medicine , cardiology , blockade , contractility , cardiac output , arterial stiffness , placebo , blood pressure , anesthesia , receptor , alternative medicine , pathology
Wave intensity analysis (WIA) is a hemodynamic index that assesses the working interaction between the heart and the arterial system. The first peak wave (W1) occurs during early systole and is associated with cardiac contractility. The second peak (W2) is associated with end systole/early diastole. A small backward‐traveling compression wave occurs after W1, referred as negative area (NA), caused by reflected waves from the peripheral (cerebral) vascular tone and resistance. There are two‐time components in WIA: R‐W1 corresponds to the pre‐ejection time and W1–W2 represents the ejection period. Recent evidence suggests that histamine receptor blockade may affect carotid arterial vessel vasodilation and arterial stiffness. PURPOSE The purpose of this study was to explore the sex differences in carotid WIA at rest and following an acute bout of exercise both in the histamine receptor blockade and control conditions. METHODS Forty‐nine healthy participants (males: n=23; females: n=26; 22 ± 1 years) were randomly assigned to either histamine receptor blockade or control placebo and underwent carotid WIA measurements at rest and at 30 (P30), 60 (P60), and 90 (P90) minutes following 45‐minute moderate intensity treadmill exercise. The effects of condition (blockade vs. control) and sex at rest were analyzed by two‐way repeated measures ANOVA. The effects of exercise, condition, and sex were analyzed by three‐way repeated measures ANOVA. RESULTS See Table 1. CONCLUSIONS Cardiac contractility is significantly increased in the histamine receptor blockade condition in men but not in women. Men also exhibit higher cerebral vascular resistance at rest. This may be associated with greater cardiovascular risk in young men compared to women, but requires further investigation. Support or Funding Information American Heart Association 12PRE9610007 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .