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Effect of Dietary Sodium Intake on Blood Pressure Variability
Author(s) -
Migdal Kamila U.,
Watso Joseph C.,
Babcock Matthew C.,
Robinson Austin T.,
Wenner Megan M.,
Stocker Sean D.,
Farquhar William B.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.714.16
Subject(s) - blood pressure , sodium , supine position , medicine , ambulatory blood pressure , excretion , endocrinology , dietary sodium , urinary system , zoology , chemistry , biology , organic chemistry
Purpose Studies in rodents have demonstrated that increased dietary sodium intake elevates blood pressure variability (BPV), independent of changes in resting blood pressure. Clinical studies have shown that increased BPV independently contributes to target organ damage and cardiovascular events. However, the effects of high dietary sodium intake on BPV in young, normotensive adults remains unknown. Therefore, the purpose of this study was to test the hypothesis that increased dietary sodium intake alters BPV in young, healthy adults. Methods Fourteen healthy, normotensive adults (7M/7W; age: 25±4 yrs; BMI: 24.7±0.9 kg/m 2 , Mean‐±SEM) participated in a controlled feeding study that consisted of 10 days of either low‐(LS:1 g sodium/day), medium‐ (MS: 2.3 g sodium/day), or high‐sodium (HS: 7 g sodium/day) diets, in randomized order. The diets were separated by at least a month. Urinary sodium excretion was determined to ensure compliance on diets. Resting beat‐to‐beat BPV was assessed in the laboratory in the supine position for ten minutes. BPV was also derived from 24‐hour ambulatory blood pressure monitoring (ABPM) to assess BPV under free‐living conditions. BPV was calculated as the average real variability index (ARV; the average of the absolute differences between consecutive blood pressure measurements) and as standard deviation (SD). Results Twenty‐four‐hour urinary sodium excretion increased in a step‐wise manner from low, to the medium, to the high sodium diets (LS: 34±6 mmol/24 hours, MS: 93±9 mmol/24, HS:275±29 mmol/24 hours, p<0.05). Dietary sodium did not alter laboratory beat‐to‐beat systolic ARV (LS=2.2±0.2 mmHg, MS= 2.0±0.2 mmHg, HS= 2.1±0.2 mmHg, p>0.05) or 24h ABPM systolic ARV (LS=9.4±0.5 mmHg, MS= 9.9±0.4 mmHg, HS=10.3±0.7 mmHg, p>0.05). Dietary sodium also did not alter laboratory beat‐to‐beat systolic SD (LS= 5.4±0.5 mmHg, MS=5.1±0.3 mmHg, HS=5.8±0.6 mmHg, p>0.05) or 24h ABPM systolic SD (LS= 12.1±0.9 mmHg, MS= 13.9±0.7 mmHg, HS= 13.1±0.9 mmHg, p>0.05). Conclusion These preliminary data suggest that 10 days of high dietary sodium intake does not alter systolic BPV in young, healthy adults. Support or Funding Information NIH Grant 1RO1HL128388 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .