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Flow‐Mediated Dilation in Obese Adolescents: Correlation with Waist Circumference and Systolic Blood Pressure
Author(s) -
Hussid Maria Fernanda,
Jordão Camila Paixão,
LopesVicente Wanda Rafaela,
Virmondes Leslie,
Cepeda Felipe,
Katayama Keyla,
FrancodeOliveira Luis Vicente,
Oliveira Ezequiel F.,
Colombo Fernanda Consolin,
Trombetta Ivani Credidio
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.713.7
Subject(s) - medicine , waist , obstructive sleep apnea , reactive hyperemia , cardiology , endothelial dysfunction , blood pressure , diabetes mellitus , metabolic syndrome , obesity , body mass index , endocrinology , blood flow
Background The increasing prevalence of obesity worldwide impacts childhood and adolescence, and this trend points to a significant growth rate of non‐transmissible chronic diseases in the near future. Endothelial dysfunction is an early marker of cardiovascular risk. Objective To determine a) whether obese adolescents have endothelial dysfunction and b) whether cardiovascular risk factors and obstructive sleep apnea (OSA) are associated with endothelial dysfunction. Methods We studied 20 obese adolescents (OA; median age 14 years, 100.9±20.3 kg), post pubescent, sedentary, not following any special diet or receiving any drug treatment, and compared them with 10 lean adolescents (LA, median age 15 years, 54.4±5.3 kg) paired for sex. Metabolic syndrome risk factors (MetS, International Diabetes Federation), vascular function (flow‐mediated dilation, FMD, and Reactive Hyperemia Index, RHI, by peripheral arterial tonometry, EndoPAT®), functional capacity and OSA using the apnea‐hypopnea index (AHI, polysomnography) were assessed. Results The OA presented higher waist (WC) and cervical circumference , as well as higher proportion of body fat, triglycerides, SBP, DBP, LDL‐c and lower HDL‐c than the LA group. In the OA, 35% presented MetS, which was absent in the LA group. OSA was present in 86.6% of the OA and 50% of LA (AHI>1 event/hour). There was no difference between groups in the AHI, VO 2 peak and RHI. The OA presented lower FMD than LA (6.17±2.72 vs. 9.37±2.20%, p=0.005). There was an association between FMD and WC (r=−0.506, p=0.008) and FMD and SBP (r=−0.493, p=0.006). Conclusion OSA was observed in most adolescents, regardless of obesity. OA presented MetS and endothelial dysfunction. Increased WC and SBP seem to be involved in this alteration. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .